Sequelae of axillary lymph node dissection in older women with Stage 1 and 2 breast carcinoma
Identifieur interne : 009872 ( Main/Exploration ); précédent : 009871; suivant : 009873Sequelae of axillary lymph node dissection in older women with Stage 1 and 2 breast carcinoma
Auteurs : Jeanne S. Mandelblatt [États-Unis] ; Stephen B. Edge [États-Unis] ; Neal J. Meropol [États-Unis] ; Ruby Senie [États-Unis] ; Theodore Tsangaris [États-Unis] ; Luther Grey [États-Unis] ; Burt Peterson [États-Unis] ; Yi-Ting Hwang [États-Unis] ; Jane C. Weeks [États-Unis]Source :
- Cancer [ 0008-543X ] ; 2002.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Personne âgée.
English descriptors
- KwdEn :
Abstract
BACKGROUND, There are few data on the long-term sequelae of axillary dissection among older breast carcinoma patients. We describe the impact of axillary dissection in a cohort of older women. METHODS. A longitudinal cohort of 571 patients with Stage 1 and 2 breast carcinoma, 67 years and older, diagnosed between 1995 and 1997 from 29 hospitals in five regions, and followed for 2 years. Data were collected from patients and medical charts. The primary outcome was posttreatment quality of life. Generalized estimation equation longitudinal modeling was used to evaluate the outcome, controlling for baseline function, comorbidity, age, clinical status, and other factors. RESULTS. Sixty percent of women reported arm problems at some time in the 2 years after surgery. The cumulative risk of having arm problems 2 years posttreatment was three times higher (95% confidence interval 1.94-4.67) for women who underwent axillary surgery compared with women without axillary surgery, controlling for covariates. The effects of having axillary dissection and arthritis were multiplicative 2 years postsurgery. Arm problems were, in turn, the primary determinate of lower physical and mental functioning (P = 0.0001 and 0.04, respectively), controlling for other factors. Undergoing axillary dissection did not lessen fears about recurrence. CONCLUSIONS. Arm problems after axillary dissection have a consistent negative impact on quality of life, suggesting that the risks may outweigh the potential benefits in this population.
Affiliations:
- États-Unis
- District de Columbia, Massachusetts, Pennsylvanie, État de New York
- New York
- Université Columbia
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000712
- to stream PascalFrancis, to step Curation: 000248
- to stream PascalFrancis, to step Checkpoint: 000742
- to stream Main, to step Merge: 009C54
- to stream Main, to step Curation: 009872
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Sequelae of axillary lymph node dissection in older women with Stage 1 and 2 breast carcinoma</title><author><name sortKey="Mandelblatt, Jeanne S" sort="Mandelblatt, Jeanne S" uniqKey="Mandelblatt J" first="Jeanne S." last="Mandelblatt">Jeanne S. Mandelblatt</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Oncology, Lombardi Cancer Center, Georgetown University</s1><s2>Washington, DC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">District de Columbia</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Medicine, Lombardi Cancer Center, Georgetown University</s1><s2>Washington, DC</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Edge, Stephen B" sort="Edge, Stephen B" uniqKey="Edge S" first="Stephen B." last="Edge">Stephen B. Edge</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Surgery, Roswell Park Cancer Institute, State University of New York at Buffalo</s1><s2>Buffalo, New York</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Meropol, Neal J" sort="Meropol, Neal J" uniqKey="Meropol N" first="Neal J." last="Meropol">Neal J. Meropol</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Division of Medical Science, Fox Chase Cancer Center</s1><s2>Philadelphia, Pennsylvania</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Division of Population Science, Fox Chase Cancer Center</s1><s2>Philadelphia, Pennsylvania</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Senie, Ruby" sort="Senie, Ruby" uniqKey="Senie R" first="Ruby" last="Senie">Ruby Senie</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Mailman School of Public Health, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Tsangaris, Theodore" sort="Tsangaris, Theodore" uniqKey="Tsangaris T" first="Theodore" last="Tsangaris">Theodore Tsangaris</name><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Department of Surgery, Lombardi Cancer Center, Georgetown University</s1><s2>Washington, DC</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Grey, Luther" sort="Grey, Luther" uniqKey="Grey L" first="Luther" last="Grey">Luther Grey</name><affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Department of Surgery, Sibley Memorial Hospital</s1><s2>Washington, DC</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Peterson, Burt" sort="Peterson, Burt" uniqKey="Peterson B" first="Burt" last="Peterson">Burt Peterson</name><affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Department of Surgery, Beth Israel Medical Center</s1><s2>New York, New York</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Hwang, Yi Ting" sort="Hwang, Yi Ting" uniqKey="Hwang Y" first="Yi-Ting" last="Hwang">Yi-Ting Hwang</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Oncology, Lombardi Cancer Center, Georgetown University</s1><s2>Washington, DC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Weeks, Jane C" sort="Weeks, Jane C" uniqKey="Weeks J" first="Jane C." last="Weeks">Jane C. Weeks</name><affiliation wicri:level="2"><inist:fA14 i1="10"><s1>Department of Medicine, Dana-Farber Cancer Institute</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">03-0090463</idno><date when="2002">2002</date><idno type="stanalyst">PASCAL 03-0090463 INIST</idno><idno type="RBID">Pascal:03-0090463</idno><idno type="wicri:Area/PascalFrancis/Corpus">000712</idno><idno type="wicri:Area/PascalFrancis/Curation">000248</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000742</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000742</idno><idno type="wicri:doubleKey">0008-543X:2002:Mandelblatt J:sequelae:of:axillary</idno><idno type="wicri:Area/Main/Merge">009C54</idno><idno type="wicri:Area/Main/Curation">009872</idno><idno type="wicri:Area/Main/Exploration">009872</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Sequelae of axillary lymph node dissection in older women with Stage 1 and 2 breast carcinoma</title><author><name sortKey="Mandelblatt, Jeanne S" sort="Mandelblatt, Jeanne S" uniqKey="Mandelblatt J" first="Jeanne S." last="Mandelblatt">Jeanne S. Mandelblatt</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Oncology, Lombardi Cancer Center, Georgetown University</s1><s2>Washington, DC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">District de Columbia</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Medicine, Lombardi Cancer Center, Georgetown University</s1><s2>Washington, DC</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Edge, Stephen B" sort="Edge, Stephen B" uniqKey="Edge S" first="Stephen B." last="Edge">Stephen B. Edge</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Surgery, Roswell Park Cancer Institute, State University of New York at Buffalo</s1><s2>Buffalo, New York</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Meropol, Neal J" sort="Meropol, Neal J" uniqKey="Meropol N" first="Neal J." last="Meropol">Neal J. Meropol</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Division of Medical Science, Fox Chase Cancer Center</s1><s2>Philadelphia, Pennsylvania</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Division of Population Science, Fox Chase Cancer Center</s1><s2>Philadelphia, Pennsylvania</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Senie, Ruby" sort="Senie, Ruby" uniqKey="Senie R" first="Ruby" last="Senie">Ruby Senie</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Mailman School of Public Health, Columbia University</s1><s2>New York, New York</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Tsangaris, Theodore" sort="Tsangaris, Theodore" uniqKey="Tsangaris T" first="Theodore" last="Tsangaris">Theodore Tsangaris</name><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Department of Surgery, Lombardi Cancer Center, Georgetown University</s1><s2>Washington, DC</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Grey, Luther" sort="Grey, Luther" uniqKey="Grey L" first="Luther" last="Grey">Luther Grey</name><affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Department of Surgery, Sibley Memorial Hospital</s1><s2>Washington, DC</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Peterson, Burt" sort="Peterson, Burt" uniqKey="Peterson B" first="Burt" last="Peterson">Burt Peterson</name><affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Department of Surgery, Beth Israel Medical Center</s1><s2>New York, New York</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Hwang, Yi Ting" sort="Hwang, Yi Ting" uniqKey="Hwang Y" first="Yi-Ting" last="Hwang">Yi-Ting Hwang</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Oncology, Lombardi Cancer Center, Georgetown University</s1><s2>Washington, DC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Weeks, Jane C" sort="Weeks, Jane C" uniqKey="Weeks J" first="Jane C." last="Weeks">Jane C. Weeks</name><affiliation wicri:level="2"><inist:fA14 i1="10"><s1>Department of Medicine, Dana-Farber Cancer Institute</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Cancer</title><title level="j" type="abbreviated">Cancer</title><idno type="ISSN">0008-543X</idno><imprint><date when="2002">2002</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Cancer</title><title level="j" type="abbreviated">Cancer</title><idno type="ISSN">0008-543X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arm</term><term>Axillary ganglion</term><term>Carcinoma</term><term>Complication</term><term>Early stage</term><term>Elderly</term><term>Lymphadenectomy</term><term>Lymphedema</term><term>Mammary gland</term><term>Sequela</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Carcinome</term><term>Glande mammaire</term><term>Stade précoce</term><term>Lymphadénectomie</term><term>Ganglion axillaire</term><term>Traitement</term><term>Lymphoedème</term><term>Complication</term><term>Séquelle</term><term>Bras</term><term>Personne âgée</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Personne âgée</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">BACKGROUND, There are few data on the long-term sequelae of axillary dissection among older breast carcinoma patients. We describe the impact of axillary dissection in a cohort of older women. METHODS. A longitudinal cohort of 571 patients with Stage 1 and 2 breast carcinoma, 67 years and older, diagnosed between 1995 and 1997 from 29 hospitals in five regions, and followed for 2 years. Data were collected from patients and medical charts. The primary outcome was posttreatment quality of life. Generalized estimation equation longitudinal modeling was used to evaluate the outcome, controlling for baseline function, comorbidity, age, clinical status, and other factors. RESULTS. Sixty percent of women reported arm problems at some time in the 2 years after surgery. The cumulative risk of having arm problems 2 years posttreatment was three times higher (95% confidence interval 1.94-4.67) for women who underwent axillary surgery compared with women without axillary surgery, controlling for covariates. The effects of having axillary dissection and arthritis were multiplicative 2 years postsurgery. Arm problems were, in turn, the primary determinate of lower physical and mental functioning (P = 0.0001 and 0.04, respectively), controlling for other factors. Undergoing axillary dissection did not lessen fears about recurrence. CONCLUSIONS. Arm problems after axillary dissection have a consistent negative impact on quality of life, suggesting that the risks may outweigh the potential benefits in this population.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>District de Columbia</li><li>Massachusetts</li><li>Pennsylvanie</li><li>État de New York</li></region><settlement><li>New York</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><country name="États-Unis"><region name="District de Columbia"><name sortKey="Mandelblatt, Jeanne S" sort="Mandelblatt, Jeanne S" uniqKey="Mandelblatt J" first="Jeanne S." last="Mandelblatt">Jeanne S. Mandelblatt</name></region><name sortKey="Edge, Stephen B" sort="Edge, Stephen B" uniqKey="Edge S" first="Stephen B." last="Edge">Stephen B. Edge</name><name sortKey="Grey, Luther" sort="Grey, Luther" uniqKey="Grey L" first="Luther" last="Grey">Luther Grey</name><name sortKey="Hwang, Yi Ting" sort="Hwang, Yi Ting" uniqKey="Hwang Y" first="Yi-Ting" last="Hwang">Yi-Ting Hwang</name><name sortKey="Mandelblatt, Jeanne S" sort="Mandelblatt, Jeanne S" uniqKey="Mandelblatt J" first="Jeanne S." last="Mandelblatt">Jeanne S. Mandelblatt</name><name sortKey="Meropol, Neal J" sort="Meropol, Neal J" uniqKey="Meropol N" first="Neal J." last="Meropol">Neal J. Meropol</name><name sortKey="Meropol, Neal J" sort="Meropol, Neal J" uniqKey="Meropol N" first="Neal J." last="Meropol">Neal J. Meropol</name><name sortKey="Peterson, Burt" sort="Peterson, Burt" uniqKey="Peterson B" first="Burt" last="Peterson">Burt Peterson</name><name sortKey="Senie, Ruby" sort="Senie, Ruby" uniqKey="Senie R" first="Ruby" last="Senie">Ruby Senie</name><name sortKey="Tsangaris, Theodore" sort="Tsangaris, Theodore" uniqKey="Tsangaris T" first="Theodore" last="Tsangaris">Theodore Tsangaris</name><name sortKey="Weeks, Jane C" sort="Weeks, Jane C" uniqKey="Weeks J" first="Jane C." last="Weeks">Jane C. Weeks</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 009872 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 009872 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:03-0090463
|texte= Sequelae of axillary lymph node dissection in older women with Stage 1 and 2 breast carcinoma
}}
| This area was generated with Dilib version V0.6.31. |  |